The research on ephedrine and caffeine is clear and extencive regarding fat loss effect. Both ephedrine and caffeine alone have moderate weight loss effect, but the effects of ephedrine and caffeine together are fare more powerful then either compound alone.
Research published in the International Journal of Obesity (17: 343-347, 1993; S:73-78, 1993; 3:S73-77, 1993; 18: 99-103, 1994), American Journal of Clinical Nutrition ( 55:246 S-282, 1992), and the Journal Metabolism (41: 1233-1241, 1992; 41: 686-688, 1992; 40:343, 1990) as well as many others, have shown colclusively that the combination of ephedrine and caffeine in the correct ratios and amounts is very effective for weight loss.This research has been done on animals and confirmed repeatedly on human studies many times.
Optimal Caffeine to Ephedrine ratio for fat loss is 10:1. The vast majority of studies have used 20mg of ephedrine and 200mg of caffeine 3 times a day for total daily dose of 60mg Ephedrine and 600mg of Caffeine.
Ephedrine, Caffeine and Aspirin?
Those who are familiar with these products have usually known the above as the "ECA stack" which stands for ephedrine, caffeine and aspirin. Aspirin was first added to EC stack about 12 years ago by two scientists at the department of medicine at Harvard Medical School. It is included in the hope that it acts as a prostaglandin inhibitor and an enhancer of lipolytic activity.
Though some studies suggest that the addition of aspirin may help with the fat loss effects of Ephedrine and Caffeine combination, there has never been a head-to-head study done that showed the ECA combination was superior to the EC without aspirin.
The vast majority of studies were in fact done on the Ephedrine+Caffeine blend. The value of including aspirin is questionable.
More Advantages of Ephedrine/Caffeine Blend
Researches show that Ephedrine plus Caffeine combo protects lean tissue (muscle) while on reduced calorie diets and this is another considerable plus for people using such products, especially athletes.
Another distinction of the Ephedrine/Caffeine blend is that they appear to work on non-exercising people. There are very few diet pills in the world that have such effect! In one recent study that examined the use of Ephedrine/Caffeine and aspirin with non-exercising people, subjects lost almost ten pounds of fat in six weeks from taking 20mg of ephedrine, 200mg of caffeine and 325mg of aspirin 3 times a day. You can read more about Ephedrine HCL Here.